Using genetic engineering to isolate and correct hair loss genes


Rather than replicating a new organism, genetic engineering alters the DNA of a particular cell so that it can manufacture proteins to correct genetic defects or produce other beneficial changes. Genetic engineering involves three steps:

1. Isolate the problem gene(s). 2. Clone (multiply) the gene(s). 3. Insert the gene inside the cell so that it can correct the problem.

The first gene causing hair loss in humans was discovered by Dr. Christiano at Columbia University. She found that individuals with this gene are born with hair that soon falls out (as infant hair often does) but then never grows back. Unfortunately, this isn’t the gene that causes male pattern baldness (which is probably the result of more than one gene), but labs are working to isolate the genes responsible for that widespread condition.

Multiplying hairs

In hair multiplication, hairs are simply plucked from the scalp or beard and implanted into the bald part of the scalp. The idea is that some germinative cells at the base of the hair follicle are pulled out along with the hair, and when the hair is implanted, these cells should be able to regenerate a new follicle at the removal site and produce a grown hair at the implant site. In other words, one beard hair removed and implanted in the bald scalp would produce a beard hair in the bald scalp and in the removal site.

In theory, microscopic examination of the plucked hair could help the doctor determine which hairs have the most stem cells attached and thus which are most likely to regrow. The procedure is called hair multiplication because the plucked follicles regrow a new hair, potentially giving an unlimited supply.

In a modification of this procedure, the bulbs of the hair are separated from the shafts and then cultivated in vitro (outside the body). After the cells multiply, they’re injected into the pores of local, dormant hair follicles in the balding area. There are three areas where stem cells can be found in the human hair:

The problem with obtaining stem cells with either technique (hair multiplication and modification) is that:

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This article was sent to us by: Kelly Makay at 06192010

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